Profhilo vs Rejuran: Unveiling the Key Distinctions

Profhilo vs Rejuran: What are the differences? A Klinik

Profhilo vs Rejuran: What are the differences? A Klinik

In the world of aesthetic medicine, there is a wide range of options available to address the signs of aging and achieve a more youthful appearance. Two popular treatments that have gained significant attention in recent years are Profhilo and Rejuran. While both aim to enhance the skin’s quality and combat aging, they employ different mechanisms and have unique properties. In this blog post, we will explore the differences between Profhilo and Rejuran to help you make an informed decision about which treatment may be best suited for your needs.

What is Profhilo?

Profhilo is an innovative injectable treatment designed to improve skin laxity and address signs of aging. It consists of a high concentration of hyaluronic acid (HA), a naturally occurring substance that plays a vital role in maintaining skin hydration and elasticity. What sets Profhilo apart is its unique composition, which combines both high and low molecular weight HA. This combination allows for optimal spreadability and penetration into the skin.

What is Rejuran?

Rejuran, on the other hand, is a regenerative skin treatment that harnesses the power of polynucleotides (PN). These are DNA fragments derived from salmon DNA that possess strong regenerative properties. Rejuran works by promoting cell growth, collagen synthesis, and skin repair, ultimately improving the skin’s texture, tone, and overall quality.

Differences between Profhilo & Rejuran


Although both treatments offer similar overall benefits, they specialize in distinct areas. Profhilo is composed of Hyaluronic Acid (HA) in high and low molecular weights, providing dual advantages. The low molecular weight HA aids in the production of HA, deeply hydrating the skin and improving moisture levels. Additionally, the high molecular weight HA stimulates the natural synthesis of collagen and elastin, enhancing skin elasticity. As a result, Profhilo is most suitable for addressing concerns such as saggy and loose skin, dryness, wrinkles, and fine lines. On the contrary, Rejuran‘s key ingredient is Polynucleotides (PDRN), which are renowned for their tissue repair properties and anti-inflammatory characteristics. PDRN assists in skin regeneration and reinforces the skin’s own protective barrier function. Consequently, Rejuran is highly effective for concerns such as open pores, acne scars, skin damage, and minor dark spots.

Injection Technique:

While both treatments involve injections, the technique and distribution of injections may vary. Profhilo injections are typically administered across specific areas of the face or body,  Profhilo requires only 5 strategically placed injections using Bioaesthetic Point (BAP) technology, whereas Rejuran utilizes microinjections to target precise areas of concern which means Rejuran requires multiple injections all over the face.

Targeted Concerns:

Profhilo is generally recommended for individuals with mild to moderate skin laxity and aging signs, whereas Rejuran is versatile and can address a broader range of skin concerns, including acne scars, fine lines, and uneven skin tone. In general, Rejuran is more effective in treating deeper wrinkles, while Profhilo is more effective in treating shallower wrinkles. Profhilo is also a safer choice for patients with sensitive skin or prone to allergic reactions. Profhilo was also better tolerated by patients who had adverse reactions to other types of treatment.


In conclusion, Profhilo and Rejuran are two distinct treatments in the realm of aesthetic medicine, each with its own unique properties and targeted benefits. When considering which treatment to choose, it is important to assess your specific skin concerns and goals.

If you are interested in exploring Profhilo and Rejuran, our A Klinik Signature will be the one for you. Whether you’re looking for skin rejuvenation, body contouring, or acne treatments, A Klinik Signature has a range of services to help you achieve your desired aesthetic goals. So why wait? Book your appointment today and take the first step towards a more confident and beautiful you!

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