Superior for treating wrinkles: Profhilo or Rejuran? - A Klinik

Superior for treating wrinkles: Profhilo or Rejuran?

Superior for treating wrinkles: Profhilo or Rejuran?

In the ever-evolving world of aesthetic medicine, the quest for the perfect solution to combat aging continues to captivate both practitioners and patients alike. Among the myriad of anti-aging treatments available, two contenders have emerged as titans in the battle against wrinkles: Profhilo and Rejuran. In this comprehensive exploration, we’ll delve into the science behind each, comparing their efficacy, mechanisms of action, and suitability for different skin types.

Understanding Profhilo: The Hyaluronic Acid Marvel

Profhilo, often hailed as a groundbreaking innovation in the realm of dermal rejuvenation, belongs to the family of hyaluronic acid (HA) injectables. Unlike traditional dermal fillers that target specific lines or volume loss, Profhilo takes a unique approach by stimulating overall skin improvement. The secret lies in its hybrid composition of high and low molecular weight HA. High molecular weight HA provides an instant hydrating effect, while the low molecular weight counterpart promotes collagen and elastin production over time. This dual-action mechanism makes Profhilo a favorite among those seeking a holistic approach to wrinkle reduction.

Understanding Rejuran: The DNA-Driven Rejuvenator

On the other side of the ring, we have Rejuran, a newcomer that has gained significant attention for its innovative use of polynucleotides (PN) derived from salmon DNA. This injectable promises not only to address wrinkles but also to revitalize the skin at a cellular level. The concept revolves around harnessing the reparative power of DNA to stimulate collagen production, enhance elasticity, and promote overall skin health.

Comparing Mechanisms of Action

To truly understand which treatment might be superior for treating wrinkles, a closer look at their mechanisms of action is imperative.


Profhilo works by providing intense hydration to the skin, thanks to its high molecular weight HA. This not only smoothens the existing wrinkles but also prevents the formation of new ones by improving skin elasticity. The low molecular weight HA, meanwhile, kick-starts collagen and elastin synthesis, ensuring long-term structural support.


Rejuran, however, takes a more intricate route. The polynucleotides extracted from salmon DNA are believed to mimic the natural biological processes of human DNA. When introduced into the skin, they are thought to repair damaged cells, boost collagen formation, and kickstart the regeneration process. This makes Rejuran a compelling choice for those seeking comprehensive skin rejuvenation.

Clinical Evidence and Efficacy

Both Profhilo and Rejuran have amassed a considerable body of clinical evidence supporting their efficacy. Studies have shown that Profhilo not only reduces wrinkles and fine lines but also enhances skin texture and firmness. Its ability to address multiple aspects of skin aging makes it a versatile option for a broad spectrum of patients.

Rejuran, too, has demonstrated promising results. The DNA-based approach appears to provide long-lasting benefits, with improvements in skin elasticity, hydration, and overall radiance. However, it’s essential to note that individual responses may vary, and factors like skin type, age, and lifestyle can influence the outcome.

Choosing the Right Treatment

Selecting the superior treatment for wrinkles ultimately boils down to individual preferences, skin conditions, and the desired outcomes. Profhilo‘s hydrating and collagen-boosting properties make it an excellent choice for those seeking a non-invasive, overall skin improvement. Rejuran, with its DNA-centric approach, may be more appealing to individuals interested in cellular-level rejuvenation and a more intensive, long-term solution.

It’s crucial to consult with a qualified aesthetic practitioner to determine which option aligns best with your skin goals. Additionally, a combination approach, using both Profhilo and Rejuran strategically, might be considered for those looking to maximize the benefits of each treatment.

Considerations for Skin Types

Skin types play a pivotal role in the success of any aesthetic treatment. Profhilo‘s hyaluronic acid formulation is generally well-tolerated across various skin types, making it a versatile option for a broad patient demographic. However, individuals with a history of hypersensitivity to HA may need to exercise caution. Rejuran‘s salmon DNA-derived polynucleotides have shown a good safety profile, but as with any procedure, a thorough consultation with a healthcare professional is essential. Those with a history of allergies or specific skin conditions should communicate these details to their practitioner for a tailored treatment plan.


In the dynamic landscape of aesthetic medicine, the battle between Profhilo and Rejuran for wrinkle supremacy continues to unfold. Each treatment brings a unique set of attributes to the table, and choosing between them is a matter of individual needs and expectations. Profhilo’s dual-action hyaluronic acid formula offers a harmonious blend of immediate hydration and long-term collagen stimulation. In contrast, Rejuran’s DNA-driven approach seeks to rejuvenate the skin at a cellular level, promising comprehensive and lasting results. To make an informed decision, individuals are encouraged to consult with experienced practitioners who can assess their unique skin characteristics and recommend a personalized approach that aligns with their aesthetic goals.

If you are still searching for the best certified aesthetic clinic in Penang that provides both of these treatments, our A Klinik Signature will be the one for you. Whether you’re looking for skin rejuvenation, body contouring, or acne treatments, A Klinik Signature has a range of services to help you achieve your desired aesthetic goals. So why wait? Book your appointment today and take the first step towards a more confident and beautiful you!

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